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pstat1 tyr 701 58d6 cell signaling  (Cell Signaling Technology Inc)


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    Cell Signaling Technology Inc pstat1 tyr 701 58d6 cell signaling
    Pstat1 Tyr 701 58d6 Cell Signaling, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 1536 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/pstat1 tyr 701 58d6 cell signaling/product/Cell Signaling Technology Inc
    Average 98 stars, based on 1536 article reviews
    pstat1 tyr 701 58d6 cell signaling - by Bioz Stars, 2026-02
    98/100 stars

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    SOCS1 T68fs immune cells hyper-respond to cytokine. A Interferon-alpha stimulation (1000 IU/mL) of whole blood and analysis of <t>STAT1</t> phosphorylation by mass cytometry as measured by mean signal intensity (MSI) and percent positive relative to unstimulated. B Interferon-gamma stimulation (10 ng/mL) of whole blood and analysis of STAT1 phosphorylation as above. C IL2 (10 ng/mL) of whole blood and analysis of STAT5 phosphorylation as above. D–I IL4 and IL13 stimulation (both 10 ng/mL) of the indicated whole blood subsets and analysis of STAT6 phosphorylation. Healthy donor (HD, pink) and patient samples (P or “SOCS1”, blue).
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    SOCS1 T68fs immune cells hyper-respond to cytokine. A Interferon-alpha stimulation (1000 IU/mL) of whole blood and analysis of <t>STAT1</t> phosphorylation by mass cytometry as measured by mean signal intensity (MSI) and percent positive relative to unstimulated. B Interferon-gamma stimulation (10 ng/mL) of whole blood and analysis of STAT1 phosphorylation as above. C IL2 (10 ng/mL) of whole blood and analysis of STAT5 phosphorylation as above. D–I IL4 and IL13 stimulation (both 10 ng/mL) of the indicated whole blood subsets and analysis of STAT6 phosphorylation. Healthy donor (HD, pink) and patient samples (P or “SOCS1”, blue).
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    SOCS1 T68fs immune cells hyper-respond to cytokine. A Interferon-alpha stimulation (1000 IU/mL) of whole blood and analysis of STAT1 phosphorylation by mass cytometry as measured by mean signal intensity (MSI) and percent positive relative to unstimulated. B Interferon-gamma stimulation (10 ng/mL) of whole blood and analysis of STAT1 phosphorylation as above. C IL2 (10 ng/mL) of whole blood and analysis of STAT5 phosphorylation as above. D–I IL4 and IL13 stimulation (both 10 ng/mL) of the indicated whole blood subsets and analysis of STAT6 phosphorylation. Healthy donor (HD, pink) and patient samples (P or “SOCS1”, blue).

    Journal: Journal of clinical immunology

    Article Title: IL4Rα and IL17A Blockade Rescue Autoinflammation in SOCS1 Haploinsufficiency

    doi: 10.1007/s10875-023-01635-z

    Figure Lengend Snippet: SOCS1 T68fs immune cells hyper-respond to cytokine. A Interferon-alpha stimulation (1000 IU/mL) of whole blood and analysis of STAT1 phosphorylation by mass cytometry as measured by mean signal intensity (MSI) and percent positive relative to unstimulated. B Interferon-gamma stimulation (10 ng/mL) of whole blood and analysis of STAT1 phosphorylation as above. C IL2 (10 ng/mL) of whole blood and analysis of STAT5 phosphorylation as above. D–I IL4 and IL13 stimulation (both 10 ng/mL) of the indicated whole blood subsets and analysis of STAT6 phosphorylation. Healthy donor (HD, pink) and patient samples (P or “SOCS1”, blue).

    Article Snippet: Antibodies against the following proteins were used: SOCS1 (ThermoFisher), Flag M2 (Sigma Aldrich), phospho-Tyr 701 STAT1 (Cell Signaling Technology), phosphor-Tyr 689 STAT2 (Cell Signaling Technology), phospho-Tyr 641 STAT6 (Cell Signaling Technology), USP18 (Cell Signaling Technology), and β-actin (Cell Signaling Technology).

    Techniques: Phospho-proteomics, Mass Cytometry

    SOCS1 T68fs fails to inhibit cytokine signaling by loss-of-expression. A SOCS1 mRNA levels by qPCR in A549 cells transduced with either empty vector (EV), WT SOCS1, or T68fs SOCS1. P-values for individual comparisons from statistical testing shown above. B Western blotting for Flag-tagged SOCS1 transfected into HEK239T cells. Immunoblotting by polyclonal SOCS1 antibodies or anti-Flag antibody. For anti-SOCS1 immunoblotting, the band present in all conditions below ~23kDa is non-specific. The horizontal arrow indicates the predicted molecular weight of T68fs SOCS1. The asterisk indicates the non-specific band. C Western blot for STAT1/2 phosphorylation by IFN-I stimulation of SOCS1-transfected HEK239T cells. D Western blot for STAT1 phosphorylation by IFN-II stimulation of SOCS1-transduced A549 cells. E Western blot for STAT6 phosphorylation by IL4 in SOCS1-transduced A549 cells. F ISRE-inducible Luciferase activity in SOCS1-transfected HEK239T cells stimulated with IFN-I. G Interferon-stimulated gene induction in SOCS1-transfected HEK239T cells stimulated with IFN-I.

    Journal: Journal of clinical immunology

    Article Title: IL4Rα and IL17A Blockade Rescue Autoinflammation in SOCS1 Haploinsufficiency

    doi: 10.1007/s10875-023-01635-z

    Figure Lengend Snippet: SOCS1 T68fs fails to inhibit cytokine signaling by loss-of-expression. A SOCS1 mRNA levels by qPCR in A549 cells transduced with either empty vector (EV), WT SOCS1, or T68fs SOCS1. P-values for individual comparisons from statistical testing shown above. B Western blotting for Flag-tagged SOCS1 transfected into HEK239T cells. Immunoblotting by polyclonal SOCS1 antibodies or anti-Flag antibody. For anti-SOCS1 immunoblotting, the band present in all conditions below ~23kDa is non-specific. The horizontal arrow indicates the predicted molecular weight of T68fs SOCS1. The asterisk indicates the non-specific band. C Western blot for STAT1/2 phosphorylation by IFN-I stimulation of SOCS1-transfected HEK239T cells. D Western blot for STAT1 phosphorylation by IFN-II stimulation of SOCS1-transduced A549 cells. E Western blot for STAT6 phosphorylation by IL4 in SOCS1-transduced A549 cells. F ISRE-inducible Luciferase activity in SOCS1-transfected HEK239T cells stimulated with IFN-I. G Interferon-stimulated gene induction in SOCS1-transfected HEK239T cells stimulated with IFN-I.

    Article Snippet: Antibodies against the following proteins were used: SOCS1 (ThermoFisher), Flag M2 (Sigma Aldrich), phospho-Tyr 701 STAT1 (Cell Signaling Technology), phosphor-Tyr 689 STAT2 (Cell Signaling Technology), phospho-Tyr 641 STAT6 (Cell Signaling Technology), USP18 (Cell Signaling Technology), and β-actin (Cell Signaling Technology).

    Techniques: Expressing, Transduction, Plasmid Preparation, Western Blot, Transfection, Molecular Weight, Phospho-proteomics, Luciferase, Activity Assay